AI for closed-risk health systems

Better outcomes and lower cost — driven by the same AI.

The Kure is an AI company applying precision medicine to closed-risk health systems — settings where a single institution owns the outcomes, the budget, and the liability for years. Our models turn genomic and clinical data into explainable, clinician-in-the-loop intelligence, so the clinical failures that cost the most are prevented before they happen.

The closed-risk thesis

In most of healthcare, better care and lower cost are opposed. In closed-risk systems — one institution, one population, many years — they align. The intelligence that prevents the costliest clinical failures improves care and recovers budget in the same step.

$1,000–$3,500
recovered per patient each year through genetics-guided prescribing
~30%
fewer adverse drug reactions when genetics inform the prescription
Top 5%
of patients drive roughly half of all spend — most of it preventable
How it works

One engine. Data in, foresight out.

The Kure learns from genomic and clinical data to produce risk and prescribing intelligence — and every outcome makes the next prediction sharper.

Genomic data
sequenced once
Clinical record
data you already hold
AI
The Kure models
learn continuously
Risk & prescribing intelligence
explainable, ranked
Better care, lower cost
failures prevented early
Every outcome retrains the models — the system sharpens with each patient, and the advantage compounds.
Two kinds of intelligence
Effective No effect Adverse

Pharmacogenomics

One sample reveals which medications will help, do nothing, or harm — so the right drug is prescribed the first time, not after a string of costly failures.

top 5%~half of cost lower riskhigher risk

Risk stratification

The whole population is ranked and refreshed continuously, surfacing the few whose rising risk drives most of the cost — early enough to act.

Where the cost is

The failures are the cost — not the drugs.

Closed-risk systems don't overspend on medication; they absorb the cost of prescribing that misses. The Kure prevents the three biggest misses.

01

Psychiatric medication cycling

Antidepressants and antipsychotics prescribed without genetic insight fail and cycle — weeks of uncontrolled illness each time.

$1,000–$3,500recovered / patient / year
02

Cardiovascular non-response

Genetics decide whether blood thinners actually protect a patient — and the first sign of failure is the cardiac event.

$50K–$150Ksaved / prevented event
03

Avoidable adverse events

Polypharmacy interactions drive preventable admissions, concentrated in the highest-risk few.

$15K–$40Kper avoided hospitalization
Who we serve

Built for closed-risk health systems.

Defined populations where a single institution owns outcomes and budgets for years — and where preventing the costly failures matters most.

Initial focus

Government-mandated care

A single authority, a long-tenure population, risk accumulating over years.

Veterans' health

Complex, longitudinal needs across a defined, enrolled population.

Aged & long-term care

Gradual, detectable, medication-heavy decline.

Disability & supported living

Sustained care for vulnerable individuals on complex regimens.

Defensibility

Built to clear the reviews it will face.

Designed to pass FDA positioning, security, and legal review — before the conversation gets there.

Not a medical device

Clinical decision support under the FDA CDS safe harbor. The basis of every recommendation is shown — no black box.

The clinician always decides

The Kure recommends; the prescriber chooses. Authority and responsibility stay with the clinician.

Provenance you can prove

Patient data is encrypted and processed under a HIPAA BAA. Models improve only on data explicitly consented for it — every consent and access recorded immutably.

Priced to be defensible

Anchored to cost-to-serve and value delivered — never backed into a savings target.

Patient data
encrypted · off-ledger
Consent & access ledger
immutable · auditable

Every consent and every model access is provably recorded — while the data itself stays encrypted and off the ledger.

Request a briefing

See what the intelligence finds in your population.

We work with a small number of institutional partners to validate and deploy. If you carry the duty of care for a defined population, we'd like to talk.

hello@thekure.ai